01.10.08 Project Start

PhenOxiGEn starts operating

New EU project coordinated by Andreas Beyer from the BIOTEC investigates the effect of genetic variation on cellular stress response

A new EU project, coordinated by Andreas Beyer of the BIOTEC together with the European Project Center of the TU Dresden is starting October 1st, 2008. The EU supports this three year project with almost € 2.5 million. The project “PhenOxiGEn” is addressing the relation of genetic variation and mechanisms that regulate oxidative stress responses of a cell. A cell’s survival depends on its ability to mount a successful stress response when challenged by damages from the environment. In humans, oxidative stress is known to be involved in aging, cancer, atherosclerosis, Alzheimer’s and Parkinson’s disease among others. These diseases are caused by a complex interplay between lifestyle and our individual genomes. Hence, not everybody is equally likely to develop such disease. Many genetic variations associated with complex diseases have been identified in the past. However, we often do not know how these variations affect the genesis of a disease. The projects aim is to extend the knowledge of the genetic factors controlling stress responses. Further partners are Jürg Bähler from the University College London, Christopher Workman from the Technical University of Denmark in Lyngby and Ruedi Aebersold from the ETH Zurich.

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